- Affordable Suites Florence
- Americas Best Value Inn/Florence
- Baymont Inn and Suites Florence
- BEST WESTERN Inn
- Comfort Inn Florence
- Comfort Suites Florence
- Country Hearth Inn Florence
- Country Inn & Suites By Carlson, Florence, SC
- Courtyard Florence
- Days Inn Florence/I-95 North
- Days Inn Florence/I-95 South
- Econo Lodge Florence
- Fairfield Inn Florence
- FLORENCE HILTON GARDEN INN
- GuestHouse Inn Florence
- Hampton Inn Suites FlorenceNorthI95
- Hampton Inn & Suites Florence-Civic Center
- Hampton Inn Florence-North
- Holiday Inn Express Hotel & Suites FLORENCE I-95 & I-20 CIVIC CTR
- Holiday Inn Express Hotel & Suites FLORENCE I-95 @ HWY 327
- Holiday Inn Hotel & Suites FLORENCE SC @ I-95 & US HWY 52
- Howard Johnson Express Inn and Suites Florence SC
- Howard Johnson Inn Florence
- Microtel Inn and Suites Florence
- Quality Inn & Suites Civic Center
- Ramada Florence SC
- Red Roof Inn Florence Civic Center
- Residence Inn Florence
- Sleep Inn Florence
- SpringHill Suites Florence
- Suburban Extended Stay Hotel
- Super 8 Florence
- Thunderbird Inn Florence
- Travel Inn Florence
- Travelodge Florence
- Wingate by Wyndham Florence
